Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines.

ABSTRACT: Immune imprinting is a phenomenon in which prior antigenic experiences influence responses to subsequent infection or vaccination^1,2. The effects of immune imprinting on serum antibody responses after boosting with variant-matched SARS-CoV-2 vaccines remain uncertain. Here we characterized the serum antibody responses after mRNA vaccine boosting of mice and human clinical trial participants. In mice, a single dose of a preclinical version of mRNA-1273 vaccine encoding Wuhan-1 spike protein minimally imprinted serum responses elicited by Omicron boosters, enabling generation of type-specific antibodies. However, imprinting was observed in mice receiving an Omicron booster after two priming doses of mRNA-1273, an effect that was mitigated by a second booster dose of Omicron vaccin

SUBMITTER: Liang CY 

PROVIDER: S-EPMC11419699 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature