Arched microfluidic channel for the promotion of axonal growth performance.

ABSTRACT: Uniformly distributed fluid shear stress can promote axonal growth, aiding in the efficient construction of functional neural interfaces. However, challenges remain in the construction of the micro-scale environment with a uniform fluidic stress distribution. In this study, we designed and fabricated a microfluidic chip with arched-section microfluidic channels (AMCs) to increase primary cortical neuron growth rate and terminal number by constructing a uniform-stress-distributed environment. Inspired by the three-dimensional (3D) microenvironment where cerebrospinal-fluid-contacting neurons are located, the surface curvature of the traditional rectangular-section microfluidic channel (RMC) was adjusted to construct structures with 3D curved surfaces. Compared with those on the RMC chips, t

SUBMITTER: Liu M 

PROVIDER: S-EPMC11419798 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature