SNP analysis of stress-related genes reveals significant correlations with drug addiction in Jordan.

ABSTRACT:

Objective

Drug addiction is a complex disorder caused by multiple factors, including environmental and genetic factors. Stress-related genes such as Galanin (GAL) and Oxytocin (OXT) have been linked to the reward pathways that contribute to the development and progression of substance addiction. This study aimed to explore the correlation between several polymorphisms of stress-related genes and drug addiction among Jordanian males.

Methods

The study included 500 participants, consisting of both healthy controls and drug-addicted Jordanian males. The genetic material and clinical data were collected, and 18 SNPs in four candidate genes were genotyped using the Sequenom MassARRAY® system. Statistical analyses were performed using the Statistical Package for the Social Science

SUBMITTER: Al-Eitan L 

PROVIDER: S-EPMC11419807 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature