Sex and obesity influence the relationship between perfluoroalkyl substances and lean body mass: NHANES 2011-2018.

ABSTRACT:

Objective

Polyfluoroalkyl substances (PFAS) are known endocrine disruptors, that have been the subject of limited research regarding their impact on human lean body mass. The aim of this study was to investigate the effects of PFAS exposure on lean body mass.

Methods

We performed a cross-sectional data analysis involving 1022 adolescents and 3274 adults from the National Health and Nutrition Examination Survey (NHANES) 2011-2018, whose lean body mass was measured by dual-energy X-ray absorptiometry. The lean mass index (LMI) was calculated as lean body mass dividing by the square of height. The association between PFAS and LMI was examined through a multivariate-adjusted weighted generalized linear model. Moreover, weighted quantile sum (WQS) regression models were employed

SUBMITTER: Jia X 

PROVIDER: S-EPMC11419868 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature