Cannabinoids Block Fat-induced Incretin Release via CB₁-dependent and CB₁-independent Pathways in Intestinal Epithelium.

ABSTRACT:

Background and aims

Glucose homeostasis is regulated by a dynamic interplay between hormones along the gastro-insular axis. For example, enteroendocrine L- and K- cells that line the intestine produce the incretins glucagon-like peptide-1 (GLP1) and glucose-dependent insulinotropic polypeptide (GIP), respectively, which are secreted following a meal. Broadly, incretin signaling enhances insulin release from the endocrine pancreas and participates in the control of food intake, and therapeutics that mimic their activity have recently been developed for the treatment of type-2 diabetes and obesity. Notably, genes for cannabinoid subtype-1 receptor (CB₁R) are expressed in these cell subpopulations; however, roles for CB₁Rs in controlling fat-induced incretin rele

SUBMITTER: Perez PA 

PROVIDER: S-EPMC11419882 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature