Mendelian randomization provides causal association between COVID-19 and thyroid cancer: insights from a multi-cancer analysis.

ABSTRACT: Since the onset of the COVID-19 pandemic, the SARS-CoV-2 virus has caused over 600 million confirmed infections and more than 6.8 million deaths worldwide, with ongoing implications for human health. COVID-19 has been extensively documented to have extrapulmonary manifestations due to the widespread expression of necessary ACE2 receptors in the human body. Nevertheless, the association between COVID-19 and cancer risk remains inadequately explored. This study employs Mendelian randomization (MR) methods to examine the causal relationship between genetic variations associated with COVID-19 and the risk of developing cancer. The findings indicate that COVID-19 has negligible impact on most cancer risks. Interestingly, a higher COVID-19 impact is associated with a decreased risk of thyroid ca

SUBMITTER: Li S 

PROVIDER: S-EPMC11419959 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature