Do NSAIDs affect bone healing rate, delay union, or cause non-union: an updated systematic review and meta-analysis.

ABSTRACT:

Introduction

Nonsteroidal anti-inflammatory drugs (NSAIDs) may potentially delay or cause non-union of fractures by inhibiting prostaglandin synthesis. However, studies have shown conflicting results. This systematic review and meta-analysis aim to synthesize current evidence on the potential influence of NSAIDs on bone healing.

Methods

We conducted a comprehensive search of PubMed, Embase, and Cochrane CENTRAL databases for studies published up to 25 July 2023. Specific keywords included "NSAID," "nonsteroidal anti-inflammatory drug," "cyclooxygenase-2 inhibitor," "bone healing," "non-union," "pseudoarthrosis," "delayed union," and "atrophic bone." Eligible studies included prospective, retrospective, and case-controlled studies assessing the correlation between NSAID use a

SUBMITTER: Chuang PY 

PROVIDER: S-EPMC11420001 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature