VCAM1: an effective diagnostic marker related to immune cell infiltration in diabetic nephropathy.

ABSTRACT:

Introduction

The role of immune cells in the pathogenesis and advancement of diabetic nephropathy (DN) is crucial. The objective of this study was to identify immune-cell-related biomarkers that could potentially aid in the diagnosis and management of DN.

Methods

The GSE96804 dataset was obtained from the Gene Expression Omnibus (GEO) database. Then, screen for intersections between differentially expressed genes (DEGs) and immune-related genes (IRGs). Identify core genes through protein-protein interaction (PPI) networks and the Cytoscape plugin. Subsequently, functional enrichment analysis was conducted. In addition, ROC analysis is performed to accurately identify diagnostic biomarkers. Apply the CIBERSORT algorithm to evaluate the proportion of immune cell infiltration.

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11420029 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature