Pharmacological fingerprint of antipsychotic drugs at the serotonin 5-HT_2A receptor.

ABSTRACT: The intricate involvement of the serotonin 5-HT_2A receptor (5-HT_2AR) both in schizophrenia and in the activity of antipsychotic drugs is widely acknowledged. The currently marketed antipsychotic drugs, although effective in managing the symptoms of schizophrenia to a certain extent, are not without their repertoire of serious side effects. There is a need for better therapeutics to treat schizophrenia for which understanding the mechanism of action of the current antipsychotic drugs is imperative. With bioluminescence resonance energy transfer (BRET) assays, we trace the signaling signature of six antipsychotic drugs belonging to three generations at the 5-HT_2AR for the entire spectrum of signaling pathways activated by serotonin (5-HT). The antipsychotic d

SUBMITTER: Gaitonde SA 

PROVIDER: S-EPMC11420065 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature