Bone mineral density as a prognostic marker in patients with biliary tract cancer undergoing surgery.

ABSTRACT:

Background

Biliary tract cancer (BTC) is one of the most aggressive malignancies and surgery represents the only curative treatment approach. However, even in patients with complete tumor resection 5-year survival rates are below 30%. So far, prognostic markers to assess the outcome of these patients are lacking. We therefore evaluated bone mineral density (BMD) as a prognostic tool in patients receiving surgery for BTC.

methods

76 BTC patients undergoing tumor resection in our clinic (Duesseldorf cohort) as well as an external validation cohort of 34 BTC patients (Cologne cohort) were included. BMD was analyzed at the first lumbar vertebra, using routine CT scans which has been proven comparable to DXA.

Results

Median overall survival (OS) of the Duesseldorf cohort a

SUBMITTER: Heinrichs L 

PROVIDER: S-EPMC11420066 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature