Sex-differential testosterone response to long-term weight loss.

ABSTRACT:

Objectives

Obesity-associated gonadal dysfunction is a common comorbidity in patients seeking weight loss interventions. We examined the incremental effect of weight loss on gonadal axes in men and women over 3 years. Changes in sex hormones were compared between dietary intervention (Diet) and bariatric procedures: Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG) and laparoscopic adjustable gastric banding (LAGB). Additional analysis assessed changes in corticotropic, somatotropic and thyroid axes after weight loss interventions.

Methods

This prospective, observational study included 61 adults with Body Mass Index >30 kg/m², mean age 51 (SD = 11) years. Endocrine parameters were measured at baseline and at 6 timepoints over 36-months.

Results

For e

SUBMITTER: Brzozowska MM 

PROVIDER: S-EPMC11420080 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature