Serotonin effects on human iPSC-derived neural cell functions: from mitochondria to depression.

ABSTRACT: Depression's link to serotonin dysregulation is well-known. The monoamine theory posits that depression results from impaired serotonin activity, leading to the development of antidepressants targeting serotonin levels. However, their limited efficacy suggests a more complex cause. Recent studies highlight mitochondria as key players in depression's pathophysiology. Mounting evidence indicates that mitochondrial dysfunction significantly correlates with major depressive disorder (MDD), underscoring its pivotal role in depression. Exploring the serotonin-mitochondrial connection, our study investigated the effects of chronic serotonin treatment on induced-pluripotent stem cell-derived astrocytes and neurons from healthy controls and two case study patients. One was a patient with antidepres

SUBMITTER: Cardon I 

PROVIDER: S-EPMC11420088 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature