Loss of mGlu₅ receptors in somatostatin-expressing neurons alters negative emotional states.

ABSTRACT: Subtype 5 metabotropic glutamate receptors (mGlu₅) are known to play an important role in regulating cognitive, social and valence systems. However, it remains largely unknown at which circuits and neuronal types mGlu₅ act to influence these behavioral domains. Altered tissue- or cell-specific expression or function of mGlu₅ has been proposed to contribute to the exacerbation of neuropsychiatric disorders. Here, we examined how these receptors regulate the activity of somatostatin-expressing (SST+) neurons, as well as their influence on behavior and brain rhythmic activity. Loss of mGlu₅ in SST+ neurons elicited excitatory synaptic dysfunction in a region and sex-specific manner together with a range of emotional imbalances including diminished s

SUBMITTER: Ramos-Prats A 

PROVIDER: S-EPMC11420089 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature