The causal relationship between human blood metabolites and risk of peripheral artery disease: a Mendelian randomization study.

ABSTRACT:

Background

Peripheral Artery Disease (PAD) is a common vascular disorder typically caused by atherosclerosis, leading to impaired blood supply to the lower extremities, resulting in pain, necrosis, and even amputation. Despite extensive research into the pathogenesis of PAD, many mysteries remain, particularly regarding its association with human blood metabolites.

Methods

To explore the causal relationship between 1,400 serum metabolites and PAD, a two-sample Mendelian randomization (MR) analysis was conducted. The Inverse Variance-Weighted (IVW) method was the primary technique used to estimate the causal impact of the metabolites on PAD. To enhance the analysis, several additional methods were employed: MR-Egger regression, weighted median, simple mode, and weighted mode.

SUBMITTER: Dong Z 

PROVIDER: S-EPMC11420124 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature