Integrative metagenomic and lipidomic analyses reveal alterations in children with obesity and after lifestyle intervention.

ABSTRACT:

Background

Despite emerging evidence linking alterations in gut microbiota to childhood obesity, the metabolic mechanisms linking gut microbiota to the lipid profile during childhood obesity and weight loss remain poorly understood.

Methodology

In this study, children with obesity were treated with lifestyle weight loss therapy. Metagenomics association studies and serum untargeted lipidomics analyses were performed in children with obesity and healthy controls before and after weight loss.

Main findings

We identified alterations in gut microbiota associated with childhood obesity, as well as variations in circulating metabolite concentrations. Children with obesity showed significant decreases in the levels of s-Rothia_kristinae and s-Enterobacter_roggenkam

SUBMITTER: Yin C 

PROVIDER: S-EPMC11420138 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature