Machine learning reveals the transcriptional regulatory network and circadian dynamics of <i>Synechococcus elongatus</i> PCC 7942.

ABSTRACT: Synechococcus elongatus is an important cyanobacterium that serves as a versatile and robust model for studying circadian biology and photosynthetic metabolism. Its transcriptional regulatory network (TRN) is of fundamental interest, as it orchestrates the cell's adaptation to the environment, including its response to sunlight. Despite the previous characterization of constituent parts of the S. elongatus TRN, a comprehensive layout of its topology remains to be established. Here, we decomposed a compendium of 300 high-quality RNA sequencing datasets of the model strain PCC 7942 using independent component analysis. We obtained 57 independently modulated gene sets, or iModulons, that explain 67% of the variance in the transcriptional response and 1) accurately reflect the ac

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC11420160 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature