Fine mapping-based multi-omics analysis interprets the gut-lung axis function of SGLT2 inhibitors.

ABSTRACT:

Background

Currently, Sodium-glucose cotransporter 2 (SGLT2) inhibitors demonstrate additional effects beyond glucose control on the gut microbiota and circulating metabolites. The gut microbiota and metabolites have been found to be useful in elucidating potential biological mechanisms of pulmonary diseases. Therefore, our study aims to investigate the effects of gut microbiota and metabolites mediating SGLT2 inhibition in 10 pulmonary diseases through Mendelian randomization (MR) research.

Methods

We conducted a two-sample, two-step MR study to assess the association between SGLT2 inhibition and 10 pulmonary diseases and to investigate the mediating effects of gut microbiota and metabolite. Gene-fine mapping and annotation of mediators by FUMA and Magma analyses were perfo

SUBMITTER: Yuan F 

PROVIDER: S-EPMC11420167 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature