NADPHnet: a novel strategy to predict compounds for regulation of NADPH metabolism via network-based methods.

ABSTRACT: Identification of compounds to modulate NADPH metabolism is crucial for understanding complex diseases and developing effective therapies. However, the complex nature of NADPH metabolism poses challenges in achieving this goal. In this study, we proposed a novel strategy named NADPHnet to predict key proteins and drug-target interactions related to NADPH metabolism via network-based methods. Different from traditional approaches only focusing on one single protein, NADPHnet could screen compounds to modulate NADPH metabolism from a comprehensive view. Specifically, NADPHnet identified key proteins involved in regulation of NADPH metabolism using network-based methods, and characterized the impact of natural products on NADPH metabolism using a combined score, NADPH-Score. NADPHnet demonstr

SUBMITTER: Pan F 

PROVIDER: S-EPMC11420228 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature