Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity.

ABSTRACT: In Bangladesh, Vibrio cholerae lineages are undergoing genomic evolution, with increased virulence and spreading ability. However, our understanding of the genomic determinants influencing lineage transmission and disease severity remains incomplete. Here, we developed a computational framework using machine-learning, genome scale metabolic modelling (GSSM) and 3D structural analysis, to identify V. cholerae genomic traits linked to lineage transmission and disease severity. We analysed in-patients isolates from six Bangladeshi regions (2015-2021), and uncovered accessory genes and core SNPs unique to the most recent dominant lineage, with virulence, motility and bacteriophage resistance functions. We also found a strong correlation between V. cholerae genomic traits and disease severity,

SUBMITTER: Maciel-Guerra A 

PROVIDER: S-EPMC11420230 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature