Making bloodwork work: the impact of sample collection, processing, and storage on plasma glutathione measurement, and implications for translation.

ABSTRACT: Psychiatry has traditionally focused on the study of neurons and neurotransmitter physiology in the pathophysiology and treatment of psychiatric disorders. A growing literature highlights REDOX imbalance (a state in which demand for antioxidants surpasses their bioavailability) as a common pathophysiology for a diverse array of brain conditions (e.g., trichotillomania, schizophrenia, autism, Parkinson's disease). REDOX imbalance is typically measured via plasma glutathione, as glutathione is critical to the adaptive antioxidant response in the brain. Accordingly, glutathione, its precursors, and/or metabolites serve as biomarkers of disease risk, therapeutic targets, and measures of treatment response. However, as with any emerging field, there are currently several different methods for c

SUBMITTER: Coden KM 

PROVIDER: S-EPMC11420238 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature