Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4.

ABSTRACT:

Background

Ferroptosis, a novel iron-ion-dependent metabolic cell death mode with lipid peroxides as the main driving substrate, plays an irreplaceable role in the development and preventive treatment of hepatocellular carcinoma. Curcumin has potent pharmacological anti-tumor effects.

Aim of the study

We aimed to evaluate the ex vivo and in vivo cancer inhibitory activity of curcumin and its specific mechanism of action.

Materials and methods

We used the hepatocellular carcinoma cell lines HepG2 and SMMC7721 to assess the direct inhibition of hepatocellular carcinoma proliferation by curcumin in vitro and a tumor xenograft model to evaluate the in vivo cancer inhibitory effect of curcumin.

Results

In this study, we found that ferroptosis's inhibitors specifical

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11420324 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature