Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study.

ABSTRACT:

Background

Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical ventilation may depend on airway patency. We hypothesized that airway closure and lung collapse, countered by positive end-expiratory pressure (PEEP), influence iNO efficacy. This could support the role of an adequate PEEP titration for inhalation therapy. The main aim of this study was to assess the effect of iNO with PEEP set above or below the airway opening pressure (AOP) generated by airway closure, on hemodynamics and gas exchange in swine models of acute respiratory distress syndrome. Fourteen pigs randomly underwent either bilateral or asymmetrical two-hit model of lung injury. Airway closure and lung collapse were measured with electrical impedance tomography as well as ventilation/perfusio

SUBMITTER: Pellegrini M 

PROVIDER: S-EPMC11420414 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature