Effective attenuation of Paraquat induced oxidative stress and Genotoxicity in testicular germ cells by vitamin E in Caprines.

ABSTRACT: Toxicological empirical research suggests that excessive utilization of paraquat, an herbicide, shows detrimental consequences on mammalian reproductive toxicity. The current study aims to study it as a reproductive toxin on the caprine testicular cells at 4- and 6-hour exposure duration. Paraquat treatment decreased the cell viability percentage and induced histological architectural alterations such as disruption of germinal epithelium, vacuolization, and pyknotic nuclei in the testis. The differential EB/AO staining also revealed an increased incidence of apoptosis after paraquat treatment at both dosages, i.e. 10 mM and 100 mM. Paraquat also induces oxidative stress, as evident via increased Malondialdehyde levels (a byproduct of lipid peroxidation) and a decline in the antioxidant cap

SUBMITTER: Rathee V 

PROVIDER: S-EPMC11420516 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature