Real world data of cabozantinib in patients with hepatocellular carcinoma: Focusing on dose setting and modification.

ABSTRACT:

Aim

To investigate the outcomes of cabozantinib in patients with unresectable hepatocellular carcinoma (uHCC), focusing on dose setting and modification.

Methods

We retrospectively analyzed 34 Japanese patients who received cabozantinib for uHCC. Trough concentrations (C_trough) of cabozantinib were also measured weekly for 6 weeks in the 18 patients.

Results

Sixteen patients received ≥40 mg (high-dose group), and 18 patients received 20 mg (low-dose group). Dose escalations were performed in 27.8% of the patients in the low-dose group. Although median duration of the first dose reduction or interruption in the low-dose group was twice that in the high-dose group (28 vs. 14 days, p < 0.001), there were no significant differences in the relative dose intensit

SUBMITTER: Okubo H 

PROVIDER: S-EPMC11420626 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature