Gut Microbial and Metabolic Features Associated With Clostridioides difficile Infection Recurrence in Children.

ABSTRACT:

Background

Recurrent Clostridioides difficile infection (CDI) is a critical clinical issue due to the increase in incidence and difficulty in treatment. We aimed to identify gut microbial and metabolic features associated with disease recurrence in a group of pediatric CDI patients.

Methods

A total of 84 children with primary CDI were prospectively enrolled in the study. Fecal samples collected at the initial diagnosis were subjected to 16S rRNA gene sequencing and targeted metabolomics analysis to profile the bacterial composition and metabolome.

Results

Twenty-six of 84 (31.0%) pediatric CDI patients experienced recurrence. The alpha diversity of the fecal microbiota was significantly lower in the recurrent group than in the nonrecurrent group, and the beta d

SUBMITTER: Li X 

PROVIDER: S-EPMC11420671 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature