DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer.

ABSTRACT:

Objective

Highly malignant pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant immunosuppressive and fibrotic tumour microenvironment (TME). Future therapeutic attempts will therefore demand the targeting of tumours and stromal compartments in order to be effective. Here we investigate whether dual specificity and tyrosine phosphorylation-regulated kinase 1B (DYRK1B) fulfil these criteria and represent a promising anticancer target in PDAC.

Design

We used transplantation and autochthonous mouse models of PDAC with either genetic Dyrk1b loss or pharmacological DYRK1B inhibition, respectively. Mechanistic interactions between tumour cells and macrophages were studied in direct or indirect co-culture experiments. Histological analyses used tissue micr

SUBMITTER: Brichkina A 

PROVIDER: S-EPMC11420735 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature