Metabolomic Signatures Differentiate Immune Responses in Avian Influenza Vaccine Recipients.

ABSTRACT:

Background

Avian influenza viruses pose significant risk to human health. Vaccines targeting the hemagglutinin of these viruses are poorly immunogenic without the use of adjuvants.

Methods

Twenty healthy men and women (18-49 years of age) were randomized to receive 2 doses of inactivated influenza A/H5N1 vaccine alone (IIV) or with AS03 adjuvant (IIV-AS03) 1 month apart. Urine and serum samples were collected on day 0 and on days 1, 3, and 7 following first vaccination and subjected to metabolomics analyses to identify metabolites, metabolic pathways, and metabolite clusters associated with immunization.

Results

Seventy-three differentially abundant (DA) serum and 88 urine metabolites were identified for any postvaccination day comparison. Pathway analysis revealed en

SUBMITTER: Howard LM 

PROVIDER: S-EPMC11420767 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature