Impact of CFTR Modulation on Pseudomonas aeruginosa Infection in People With Cystic Fibrosis.

ABSTRACT:

Background

Pseudomonas aeruginosa is a multidrug-resistant pathogen causing recalcitrant pulmonary infections in people with cystic fibrosis (pwCF). Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have been developed that partially correct the defective chloride channel driving disease. Despite the many clinical benefits, studies in adults have demonstrated that while P. aeruginosa sputum load decreases, chronic infection persists. Here, we investigate how P. aeruginosa in pwCF may change in the altered lung environment after CFTR modulation.

Methods

P. aeruginosa strains (n = 105) were isolated from the sputum of 11 chronically colonized pwCF at baseline and up to 21 months posttreatment with elexacaftor-tezacaftor-ivacaftor or tezacaftor-ivacaftor. Ph

SUBMITTER: Ledger EL 

PROVIDER: S-EPMC11420785 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature