Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate.

ABSTRACT: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.

Clinical trials registration

Australian New Zealand Clinical Trials Registry ACTRN12607000552482.

SUBMITTER: Persson KEM 

PROVIDER: S-EPMC11420798 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature