Ratiometric Molecularly Imprinted Particle Probes for Reliable Fluorescence Signaling of Carboxylate-Containing Molecules.

ABSTRACT: In addition to sensitivity, selectivity, and portability, chemical sensing systems must generate reliable signals and offer modular configurability to address various small molecule targets, particularly in environmental applications. We present a versatile, modular strategy utilizing ratiometric molecularly imprinted particle probes based on BODIPY indicators and dyes for recognition and internal referencing. Our approach employs polystyrene core particles doped with a red fluorescent BODIPY as an internal standard, providing built-in reference for environmental influences. A molecularly imprinted polymer (MIP) recognition shell, incorporating a green-fluorescent BODIPY indicator monomer with a thiourea binding site for carboxylate-containing analytes, is grafted from the core particles i

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11420868 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature