Synthesis, Photo-Characterizations, and Pre-Clinical Studies on Advanced Cellular and Animal Models of Zinc(II) and Platinum(II) Sulfonyl-Substituted Phthalocyanines for Enhanced Vascular-Targeted Photodynamic Therapy.

ABSTRACT: Two phthalocyanine derivatives tetra-peripherally substituted with tert-butylsulfonyl groups and coordinating either zinc(II) or platinum(II) ions have been synthesized and subsequently investigated in terms of their optical and photochemical properties, as well as biological activity in cellular, tissue-engineered, and animal models. Our research has revealed that both synthesized phthalocyanines are effective generators of reactive oxygen species (ROS). PtSO₂tBu demonstrated an outstanding ability to generate singlet oxygen (Φ_Δ = 0.87-0.99), while ZnSO₂tBu in addition to ¹O₂ (Φ_Δ = 0.45-0.48) generated efficiently other ROS, in particular ·OH. Considering future

SUBMITTER: Repetowski P 

PROVIDER: S-EPMC11420872 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature