Metric comparison of connectome-based lesion-symptom mapping in post-stroke aphasia.

ABSTRACT: Connectome-based lesion-symptom mapping relates behavioural impairments to disruption of structural brain connectivity. Connectome-based lesion-symptom mapping can be based on different approaches (diffusion MRI versus lesion mask), network scales (whole brain versus regions of interest) and measure types (tract-based, parcel-based, or network-based metrics). We evaluated the similarity of different connectome-based lesion-symptom mapping processing choices and identified factors that influence the results using multiverse analysis-the strategy of conducting and displaying the results of all reasonable processing choices. Metrics derived from lesion masks and diffusion-weighted images were tested for association with Boston Naming Test and Token Test performance in a sample of 50 participa

SUBMITTER: Ding J 

PROVIDER: S-EPMC11420983 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature