Subcortical volumes in offspring with a multigenerational family history of depression - A study across two cohorts.

ABSTRACT:

Background

Having multiple previous generations with depression in the family increases offspring risk for psychopathology. Parental depression has been associated with smaller subcortical brain volumes in their children, but whether two prior generations with depression is associated with further decreases is unclear.

Methods

Using two independent cohorts, 1) a Three-Generation Study (TGS, N = 65) with direct clinical interviews of adults and children across all three generations, and 2) the Adolescent Brain Cognitive Development Study (ABCD, N = 10,626) of 9-10 year-old children with family history assessed by a caregiver, we tested whether having more generations of depression in the family was associated with smaller subcortical volumes (using structural MRI).

Results

SUBMITTER: van Dijk MT 

PROVIDER: S-EPMC11420999 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature