Cellular and In Vivo Response to Industrial, Food Grade, and Photocatalytic TiO₂ Nanoparticles.

ABSTRACT: We encounter titanium dioxide nanoparticles (TiO₂ NPs) throughout our daily lives in the form of food coloring, cosmetics, and industrial materials. They are used on a massive industrial scale, with over 1 million metric tons in the global market. For the workers who process these materials, inhalation is a major concern. The goal of our current research is to provide a direct comparison of the three major types of TiO₂ NPs (P25, E171, R101) in terms of surface characterization, cellular response, and in vivo response following introduction into the lungs of mice. In both cellular and in vivo experiments, we observe a pro-inflammatory response to the P25 TiO₂ NPs that is not observed in the E171 or R101 TiO₂ NPs at mass-matched conc

SUBMITTER: Heckman MM 

PROVIDER: S-EPMC11421087 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature