Emergence and transmission of the high-risk ST78 clone of OXA-48-producing Enterobacter hormaechei in a single hospital in Taiwan.

ABSTRACT: Carbapenem-resistant Enterobacter cloacae complex is a significant global healthcare threat, particularly carbapenemase-producing Enterobacter hormaechei (CPEH). From January 2017 to January 2021, twenty-two CPEH isolates from a regional teaching hospital in central Taiwan were identified with the carriage of carbapenemase genes bla_KPC-2, bla_IMP-8, and predominantly bla_OXA-48. Over 80% of these CPEH strains clustered into the high-risk ST78 lineage, carrying a bla_OXA-48 IncL plasmid (pOXA48-CREH), nearly identical to the endemic plasmid pOXA48-KP in ST11 Klebsiella pneumoniae. This OXA-48-producing ST78 lineage disseminated clonally from 2018 to 2021 and transferred pOXA48-CREH to ST66 and S

SUBMITTER: Chen CM 

PROVIDER: S-EPMC11421146 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature