Real-world evidence of direct oral anticoagulants in patients with atrial fibrillation and cancer: A meta-analysis.

ABSTRACT:

Background

Several observational cohort studies have been conducted to investigate the effectiveness and safety of direct oral anticoagulants (DOACs) compared with vitamin K antagonists (VKAs) in patients who have both atrial fibrillation (AF) and cancer. Herein, we conducted a meta-analysis to present a comprehensive overview of the real-world evidence on DOACs in patients with AF and cancer.

Methods

A comprehensive search strategy was performed in PubMed and Embase until February 2024 for studies that enrolled AF patients with cancer who received DOACs or VKAs. The adjusted risk ratios (RRs) and 95% confidence intervals (CIs) of each outcome were extracted and pooled by a random-effects model.

Results

Seven observational cohort studies were eligible for data

SUBMITTER: Li X 

PROVIDER: S-EPMC11421282 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature