Divergent input patterns to the central lateral amygdala play a duet in fear memory formation.

ABSTRACT: Somatostatin (SOM)-expressing neurons in the central lateral amygdala (CeL) are responsible for fear memory learning, but the circuit and molecular mechanisms underlying this biology remain elusive. Here, we found that glutamatergic neurons in the lateral parabrachial nucleus (LPB) directly dominated the activity of CeL^SOM neurons, and that selectively inhibiting the LPB^Glu→CeL^SOM pathway suppressed fear memory acquisition. By contrast, inhibiting CeL-projecting glutamatergic neurons in the paraventricular thalamic nucleus (PVT) interfered with consolidation-related processes. Notably, CeL^SOM-innervating neurons in the LPB were modulated by presynaptic cannabinoid receptor 1 (CB1R), and knock down of CB1Rs in LPB glutamatergic neurons enhanced ex

SUBMITTER: Gao JH 

PROVIDER: S-EPMC11421289 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature