Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age.

ABSTRACT:

Background

DNA methylation-derived epigenetic clocks and frailty are well-established biological age measures capturing different aging processes. However, whether they are dynamically linked to each other across chronological age remains poorly understood.

Methods

This analysis included 1 309 repeated measurements in 524 individuals aged 50-90 years from the Swedish Adoption/Twin Study of Aging. Frailty was measured using a validated 42-item frailty index (FI). Five epigenetic clocks were calculated, including 4 principal component (PC)-based clocks trained on chronological age (PCHorvathAge and PCHannumAge) and aging-related physiological conditions (PCPhenoAge and PCGrimAge), and a pace of aging clock (DunedinPACE). Using dual change score models, we examined the dynamic,

SUBMITTER: Mak JKL 

PROVIDER: S-EPMC11421301 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature