More early bleeds associated with high baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study.

ABSTRACT:

Abstract

Treatment with direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) is effective and safe. However, bleeding complications still occur. Whether DOAC level measurement may further improve treatment efficacy and safety is still an open issue. In the "Measure and See" study, venous blood was collected 15-30 days after DOAC initiation in patients with AF who were then followed up for 1 year to record the occurrence of major and clinically relevant nonmajor bleeding. DOAC plasma levels were measured in 1 laboratory, and results were kept blind to patients and treating doctors. Trough DOAC levels were assessed in 1657 patients (957 [57.7%] and 700 patients treated with standard and low-dose, respectively). Fifty bleeding events were recorded during 1606 y

SUBMITTER: Palareti G 

PROVIDER: S-EPMC11421315 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature