Characteristics and clinical outcomes of breast cancer in young BRCA carriers according to tumor histology.

ABSTRACT:

Background

Young women with breast cancer (BC) have an increased chance of carrying germline BRCA pathogenic variants (PVs). Limited data exist on the prognostic impact of tumor histology (i.e. ductal versus lobular) in hereditary breast cancer.

Methods

This multicenter retrospective cohort study included women aged ≤40 years with early-stage breast cancer diagnosed between January 2000 and December 2020 and known to carry germline PVs in BRCA1/2. Histology was locally assessed in each center. The Kaplan-Meier method and Cox regression analysis were used to assess disease-free survival and overall survival.

Results

Of 4628 patients included from 78 centers worldwide, 3969 (86%) had pure ductal, 135 (3%) pure lobular, and 524 (11%) other histologies. Compared with duct

SUBMITTER: Agostinetto E 

PROVIDER: S-EPMC11421331 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature