Short term air pollution exposure during pregnancy and associations with maternal immune markers.

ABSTRACT:

Background

Air pollution exposure during pregnancy has been associated with numerous adverse pregnancy, birth, and child health outcomes. One proposed mechanism underlying these associations is maternal immune activation and dysregulation. We examined associations between PM_2.5 and NO₂ exposure during pregnancy and immune markers within immune function groups (TH1, TH2, TH17, Innate/Early Activation, Regulatory, Homeostatic, and Proinflammatory), and examined whether those associations changed across pregnancy.

Methods

In a pregnancy cohort study (n = 290) in Rochester, New York, we measured immune markers (using Luminex) in maternal plasma up to 3 times during pregnancy. We estimated ambient PM_2.5 and NO₂ concentrations at partici

SUBMITTER: Yount CS 

PROVIDER: S-EPMC11421383 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature