Impact of donor transaminases on liver transplant utilisation and unnecessary organ discard: national registry cohort study.

ABSTRACT:

Background

Donor liver transaminases (ALT and AST) have been used to decline livers for transplant, despite evidence that they do not influence transplant outcomes. This study assesses the effect that raised donor transaminases have on the unnecessary decline of livers.

Methods

This retrospective cohort study used the National Health Service registry on adult liver transplantation (2016-2019). Logistic regression models were built to assess the impact of donor transaminases on the utilisation of organs donated following brain stem death (DBD) and circulatory death (DCD). A further model was used to simulate the impact on liver decline if raised donor ALT was not used to make utilisation decisions.

Results

5,424 adult livers were offered for transplant, of which 3,605

SUBMITTER: Dobbins JJ 

PROVIDER: S-EPMC11421386 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature