Description of the new HIV-1 intersubtype B/C circulating recombinant form (CRF146_BC) detected in Brazil.

ABSTRACT:

Background

The human immunodeficiency virus 1 (HIV-1) infections in Brazil are predominantly caused by two subtypes, B and C.

Objectives

Here we present the characterisation of a novel HIV-1 recombinant form, indicating a new Brazilian CRF_BC, named CRF146_BC.

Methods

RDP, JphMM and Simplot recombination tools were used to evaluate the mosaic pattern.

Findings

In this work, we identified three HIV-1 nucleotide sequences previously classified as unique recombinant forms (URFs), plus one new partial genome sharing the same BC recombination pattern. The mosaic genome is almost entirely represented by the subtype C sequence, with a small subtype B recombination region in the pol gene, at the Integrase level. The phylogenetic analyses strongly indicate a common orig

SUBMITTER: Oliveira RC 

PROVIDER: S-EPMC11421422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature