Gas-Phase Structures of Fucosylated Oligosaccharides: Alkali Metal and Halogen Influences.

ABSTRACT: Fucosylated carbohydrate antigens play critical roles in physiology and pathology with function linked to their structural details. However, the separation and structural characterization of isomeric fucosylated epitopes remain challenging analytically. Here, we report for the first time the influence of alkali metal cations (Li⁺, Na⁺, K⁺, Rb⁺, and Cs⁺) and halogen anions (Cl^-, Br^-, and I^-) on the gas-phase conformational landscapes of common fucosylated trisaccharides (Lewis A, X, and H types 1 and 2) and tetrasaccharides (Lewis B and Y) using trapped ion mobility spectrometry coupled to mass spectrometry and theoretical calculations. Inspection of the mobility profiles of individual standards showed a

SUBMITTER: Miller SA 

PROVIDER: S-EPMC11421426 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature