The amalgam of naive CD4⁺ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response.

ABSTRACT: Naive CD4⁺ T cells in specific pathogen-free (SPF) mice are characterized by transcriptional heterogeneity and subpopulations distinguished by the expression of quiescence, the extracellular matrix (ECM) and cytoskeleton, type I interferon (IFN-I) response, memory-like, and T cell receptor (TCR) activation genes. We demonstrate that this constitutive heterogeneity, including the presence of the IFN-I response cluster, is commensal independent insofar as being identical in germ-free and SPF mice. By contrast, Nippostrongylus brasiliensis infection altered this constitutive heterogeneity. Naive T cell-intrinsic transcriptional changes acquired during helminth infection correlated with and accounted for decreased immunization response to an unrelated antigen. These compositional an

SUBMITTER: Even Z 

PROVIDER: S-EPMC11421571 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature