Mice and Rats Exhibit Striking Inter-species Differences in Gene Response to Acute Stroke.

ABSTRACT: Neuroprotection in acute stroke has not been successfully translated from animals to humans. Animal research on promising agents continues largely in rats and mice which are commonly available to researchers. However, controversies continue on the most suitable species to model the human situation. Generally, putative agents seem less effective in mice as compared with rats. We hypothesized that this may be due to inter-species differences in stroke response and that this might be manifest at a genetic level. Here we used whole-genome microarrays to examine the differential gene regulation in the ischemic penumbra of mice and rats at 2 and 6 h after permanent middle cerebral artery occlusion (pMCAO; Raw microarray CEL data files are available in the GEO database with an accession number GS

SUBMITTER: Wu QJ 

PROVIDER: S-EPMC11421588 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature