Dichotomy in Growth and Invasion from Low- to High-Grade Glioma Cellular Variants.

ABSTRACT: Glial dysfunction outraging CNS plasticity and integrity results in one of the most dangerous cancers, namely glioma, featuring little median survival period and high recurrence. The hallmark properties of proliferation, invasion and angiogenesis with the infiltrated macrophages in glioma are expected to be tightly coupled or cross-linked, but not properly related so far. The present study is aimed to find a relationship between this featured quadrangle from lower to higher grades (HG) of post-operative glioma tissues and their invading subsets. Elevated Ki67-associated proliferation in lower grades (LG) was supported with VEGF dependent angiogenic maintenance which found a decrease unlikely in HG. In contrast, MMP 2 and 9-associated invasions augmented high in HG with the dominant presenc

SUBMITTER: Ghosh K 

PROVIDER: S-EPMC11421645 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature