Effector memory-type regulatory T cells display phenotypic and functional instability.

ABSTRACT: Regulatory T cells (T_reg cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity and function of T_reg cells. However, impurities and functional instability pose challenges for the development of safe gene-edited T_reg cell products. Here, we examined different T_reg cell subsets regarding their fate, epigenomic stability, transcriptomes, T cell receptor repertoires, and function ex vivo and after manufacturing. Each T_reg cell subset displayed distinct features, including lineage stability, epigenomics, surface markers, T cell receptor diversity, and transcriptomics. Earlier-differentiated memory T_reg cell pop

SUBMITTER: Wendering DJ 

PROVIDER: S-EPMC11421655 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature