Glutamatergic System is Affected in Brain from an Hyperthermia-Induced Seizures Rat Model.

ABSTRACT: One of the most frequent neurological disorders in children is febrile seizures (FS), a risk for epilepsy in adults. Glutamate is the main excitatory neurotransmitter in CNS acting through ionotropic and metabotropic receptors. Excess of glutamate in the extracellular space elicits excitotoxicity and has been associated with neurological disorders, such as epilepsy. The removal of extracellular glutamate by excitatory amino acid transporters (EATT) plays an important neuroprotective role. GLT-1 is the main EAAT present in the cortex brain. On the other hand, an increase in metabotropic glutamate receptors 5 (mGlu₅R) levels or their overstimulation have been related to the appearance of seizure events in different animal models and in temporal lobe epilepsy in humans. In this wor

SUBMITTER: Crespo M 

PROVIDER: S-EPMC11421758 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature