Causal associations of air pollution with rheumatoid arthritis: A transethnic Mendelian randomization study.

ABSTRACT:

Background

Rheumatoid arthritis is a common rheumatic disease, and its onset is closely related to genetic and environmental factors, however, the relationship between air pollution and RA is still hotly debated. Further investigation of the relationship between air pollution and rheumatoid arthritis is conducive to a comprehensive understanding of the risk factors of the disease, providing certain value for the clinical prevention and treatment of RA.

Methods

We used a Two-Sample Mendelian Randomization approach, integrating the large-scale public genomewide association study, to assess the genetically predicted causal effect of air pollution (including: PM2.5, PM2.5-10, PM10, nitrogen dioxide, nitrogen oxides) on RA in European and European East Asian populations, respecti

SUBMITTER: He A 

PROVIDER: S-EPMC11421788 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature